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Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

  Stefano Cosma,¬†Andrea Roberto Carosso,¬†Silvia Corcione,¬†Jessica Cusato,¬†Fulvio Borella,¬†Miriam Antonucci,¬†Luca Marozio,¬†Alberto Revelli,¬†Mario Preti,¬†Valeria Ghisetti,¬†Giovanni Di Perri,¬†Chiara Benedetto   J Reprod Immunol .¬†2021 Apr;144:103285.¬†doi: 10.1016/j.jri.2021.103285.¬†Epub 2021 Feb 2. ¬† Abstract   We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.

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